CHRISTIAN Chabbert 5

Chargé de Recherche CNRS

Directeur GDR Vertige (http://gdrvertige.com)

Amidex GDR

Research

Dr C Chabbert has devoted his research activity over the two last decades, to understand how the vestibular end organs encode and transfer the vestibular sensory information to the brain stem, and how these processes may be altered under pathological conditions.

He sat up several experimental models that provided direct access to the inner ear compartments and cell types for cellular and molecular investigations. Using original in vitro preparations, he conducted several studies that provided better understanding of the mechanisms of the endolymph homeostasis, vestibular primary synapses setting and function. These in vitro models provided first evidence of the robust plasticity of vestibular primary synapses following selective damages.

He also developed rodent models of vestibular disorders encountered in human that allowed correlating the characteristics of the peripheral damage to the posturo-locomotor alterations encountered in the acute vestibular syndrome. These different studies conducted to several patent fillings and allowed the inception, in collaboration wit Inserm Transfert, of a biotechnology company that develops therapeutic solutions for the inner ear pathologies.

His current projects intend to decipher how a vestibular insult develops into the inner ear and how it characteristics govern the heterogeneity of vertigo symptoms. In turn they ambition to identify specific biomarkers of the different types and stages of acquired vestibular disorders. These research programs aim providing novel tools to improve the management of the dizzy patients. 

Biography

  • Director Team Pathophysiology and Therapy of Vestibular Disorders (CNRS-AMU) (2018-2022)
  • Director Thematic School VERTINNOVATION (CNRS) (2016-2018)
  • Director & Founder French Group on Vertigo Research (GDR Vertige # 3698) (2015-2018)
  • Laureate Price 2016 of the Japanese Society for Research on Balance
  • Associate Editor JARO (1rst journal for research physiology & pathology of inner ear) (2012-2017)
  • Head Study Group of Vestibular Disorders – INSERM U583 (2006-2010)
  • Founder Biotech Company Sensorion-pharmaceuticals (sensorion-pharma.com) (2009)
  • Research Associate at the Rockefeller Institute New York USA (1995)
  • Postdoctoral associate at Howard Hughes Medical Institute Dallas Texas USA (1994)

Model:

  • Cultures of vestibular primary neurons and cocultures with vestibular hair cells
  • Organotypic cultures of vestibular endorgans – Utricle cyst
  • Rodant models of vestibular insults (ototoxicity, excitotoxicity, surgical vestibular neurectomy)

Methods:

  • Two photon calcium imaging
  • Patch-clamp
  • Immunocytochemistry (protein location, inner ear synapse quantification)
  • Behavioural testing of posturo-locomotion in rodents

 

10 Main publications :

  • Cassel R, Bordiga P, Pericat D, Hautefort C, Tighilet B, Chabbert C. New mouse model for inducing and evaluating unilateral vestibular deafferentation syndrome. Journal of Neuroscience Methods. (2018) Jan 1; 293:128-135.
  • Tighilet B, Péricat D, Frelat A, Cazals Y, Rastoldo G, Boyer F, Dumas O, Chabbert C. Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit. PLoS One (2017) Nov 7; 12(11): e0187472.
  • Gaboyard-Niay S, Travo C, Saleur A, Brugeaud A, Chabbert C. Correlation between afferent rearrangements and behavioral deficits after local excitotoxic insult in the mammal vestibule: an animal model of vertigo symptoms? Disease Models and Mechanisms (2016) 9: 1181-1192.
  • Maltret A, Wiener-Vacher S, Denis C, Extramiana F, Morisseau-Durand MP, Fressart V, Bonnet D, Chabbert C. Type 2 Short QT syndrome and vestibular dysfunction: mirror of the Jervell and Lange-Nielsen syndrome? International Journal of cardiology (2014) 171(2): 291-3.
  • Desmadryl G, S Gaboyard-Niay, A Brugeaud, C Travo, A Saleur, J Dyhrfjeld-Johnsen, C Chabbert. Histamine H4 receptor antagonists as potent modulator of mammal vestibular function. British Journal of Pharmacology (2012) Oct; 167(4): 905-16.
  • Albert ES, Bec JM, Desmadryl G, Chekroud K, Travo C, Gaboyard S, Bardin F, Marc I, Dumas M, Lenaers G, Hamel C, Muller A, Chabbert C. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. Journal of Neurophysiology (2012) Jun; 107 (12):3227-34.
  • Dalet A, Bonsacquet J, Gaboyard-Niay S, Calin-Jageman I, Chidavaenzi RL, Desmadryl G, Goldberg JM, Lysakowski A, Chabbert C. Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings. PLosOne (2012) 7(9): e46261.
  • Bartolami S, Gaboyard S, Quentin J, Travo C, Cavalier M, Barhanin J, Chabbert C. Critical roles of transitional cells and Na/K-ATPase in the formation of vestibular endolymph. Journal of Neuroscience (2011) Nov 16; 31 (46): 16541-9.
  • Ruel J*, Chabbert C* (*co-first authors), Nouvian R, Bendris R, Eybalin M, Leger C, Bourien J, Mersel M, Puel JL. Salicylate enables cochlear arachidonic acid sensitive NMDA receptor Journal of Neuroscience (2008) Jul 16; 29:7313-23.
  • Brugeaud A, Travo C, Dememes D, Llorens J, Puel JL, Chabbert C. Control of hair cell excitability by vestibular primary sensory neurons. Journal of Neuroscience (2007) 27: 3503-3511.

 

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