Sensory and Cognitive Rehabilitation Team, LNSC, Marseille, France (2014 – present)
- Research field
Study of cognitive and neurobiological mechanisms associated with brain dysfunction and cognitive recovery
Summary: This project aims at identifying markers to distinguish differences between low and high cognitive performers, in the elderly. We hypothesize that by dividing the neurotypical elderly into three sub-populations (low-performers, high-performers with cognitive reserve, and high-performers with brain maintenance) based on cognitive, neuro-anatomical (cortical thickness, brain volume), and neurofunctional data (resting state connectivity), the project will help us better understanding the sensory (visual and auditory inputs, sensory processing quality), and neurobiological (genetic expression in rodents) correlates of cognitive performance in the elderly. In a social context, where the elderly are seeking to age as well as possible, understanding the exact differences between low and high performers will bring new perspectives to the field of cognitive prevention and stimulation, by providing more pertinent and direct targets.
Objective 1: To identify markers that allow us to distinguish differences between low performers and high performers, in the elderly.
Objective 2: To investigate whether cognitive remediation using these markers in a homogeneous population of 50 years allows cognitive maintenance in all subjects or not. In this case, the question will be whether this cognitive maintenance is associated with anatomo-functional maintenance in all subjects or with the implementation of compensation phenomena in those who were destined to be “low performers”.
- Study in progress
In order to study the consequences of massive hearing loss on social behaviour and cognitive performance, we subjected rats to acoustic trauma. After the trauma, half of the deaf animals were placed in a standard environment and the other half in an enriched environment (3 months before the start and throughout the behavioural assessment). The objective is to study the possible preventive role of environmental stimulation on the negative consequences of peripheral hearing loss. Our preliminary results show that hearing loss is associated with: 1) a change in social interactions (vocalizations and physical interactions); 2) a long-term memory deficit (object recognition) and a transient impairment in spatial learning (Morris water maze); 3) but has no effect on stress levels. We also observed that environmental enrichment prevented cognitive deficits and induced social behaviour different from that observed in standard environment deaf animals. We are currently analyzing data obtained in immunohistochemistry in these same animals in order to propose cellular correlates 1) to the social and cognitive changes observed following the auditory lesion; 2) as well as to the protective action of environmental stimulation.
- Brain imaging (anatomical and functional MRI)
- Cognitive tests
- Behavioural tests (memory, social interactions)
- DNA chips
- Teaching activity
- Degree inPNAC: Executive functions (EU: Epistemologies of brain sciences)
- Degree in Psychology: Executive Functions and Pathologies (EU: Neuropathologies); Attention and Executive Functions (EU: Cognitive and Behavioural Neurosciences); Directed Genetics (EU: Biology)
- Degree in LSSS: Tutored course
- Master AGIS: Cell ageing and associated pathologies (EU: Neurosciences)
- Master of Neuroscience: Cognitive Training (EU: Ontogenesis, Aging, Adaptation, Rehabilitation); Learning by “Alzheimer” Problem
Riffault B, Kourdougli N, Dumon C, Ferrand N, Buhler E, Schaller F, Chambon C, Rivera C, Gaiarsa JL, Porcher C – Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures. Cereb Cortex. Epub ahead of print
Paban V, Valable S, Baril N, Gilbert V, Chambon C, Alescio-Lautier B – Neuronal and Glial Changes in Rat Hippocampal Formation after Cholinergic Deafferentation. Biomol Res Ther. 5:3 DOI: 10.4172/2167-7956.1000147.
Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-saidi K, Jeggo R, Staniaszek L, Spanswick D, O’hare E, Palmer P, Kim E, Bywalez W, Egger V and Parsons CG. MRZ-99030 – a novel modulator of Abeta aggregation: II – reversal of Abeta oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology. 92:170-82.
Chambon C, Herrera C, Romaiguere P, Paban V, Alescio-Lautier B. (2014) Benefits of computer-based memory and attention training in healthy older adults. Psychol Aging. 29(3):731-43. doi: 10.1037/a0037477.
Alescio-Lautier B, & Chambon C. (2013) Les méthodes de remédiation de la mémoire dans le cadre du vieillissement cognitif et des pathologies qui lui sont liées. Presse Universitaire de Provence, Sous presse.
Paban V, Billard JM, Bouet V, Freret T, Boulouard M, Chambon C, Lorio B, Alescio-Lautier B. (2013) Genomic transcriptional profiling identifies candidate genes for successful aging”, Brain Struct Funct. Epub DOI 10.1007/s00429-012-0472-8.
Chambon C, Jatzke C, Wegener N, Gravius A, Danysz D. (2012) Cholinergic M1 receptor positive allosteric modulators, a promising approach for the treatment of Alzheimer’s disease. Eur J of Pharm. 697(1-3):73-80.
Herrera C, Chambon C, Michel B, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia, 50(8):1871-1881.
Delcour M, Olivier P, Chambon C, Pansiot J, Russier M, Liberge M, Xin D, Gestreau C, Alescio-lautier B, Gressens P, Verney C, Barbe MF, Baud O, Coq JO. (2011) Neuroanatomical, Sensorimotor and Cognitive Deficits in Adult Rats with White 4 Matter Injury following Prenatal Ischemia. Brain Pathology, 22(1):1-16.
Chambon C, Wegener N, Gravius A, Danysz D. (2011) Behavioural and cellular effects of exogenous amyloid-β peptides in rodents. Behav Brain research, 225(2):623-641.
Wegener N, Nagel J, Gross R, Chambon C, Pietraszek M, Greco S, Gravius A, Danysz D. (2011) Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour. Neuroscience Letters, 503(1):68-72.
Chambon C, Wegener N, Gravius A, Danysz D. (2011) A new automated method to assess the rat’s recognition memory: validation of the method. Behav Brain research, 222:151-157.
Paban V, Chambon C, Farioli F, Alescio-lautier B. (2011) Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult. Neurobiol Learn Mem, 95(4):441-52.
Gravius A, Laszy J, Pietraszek M, Saghy K, Nagel J, Chambon C, Wegener N, Valastro B, Danysz W, Gyertyan I. (2011) Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity. Behav Pharmacol. 22(2):122-35.
Paban V, Farioli F, Romier B, Chambon C, Alescio-lautier B. (2010). Gene expression profile in rat hippocampus with and without memory deficit. Neurobiol Learn Mem, 94(1):42-56.
Paban V, Chambon C, Manrique C, Touzet C, Alescio-lautier B. (2011). Neurotrophic signaling molecules associated with cholinergic damage in young and aged rats. Environmental enrichment as potential therapeutic agent. Neurobiology of aging, 32(3):470-85.
Chambon C, Wegener N, Gravius A, Danysz D. (2009) A new automated method to assess the rat’s recognition memory: validation of the method. Abstract in Behav Pharmacol, 20 (Special issue 1): S89.
Pietraszek G, Gravius A, Chambon C, Valastro B, Némethy Z, Laszy J, Sághy K, Gyertyán I, Danysz W. (2009) The effect of 5-HT6 antagonists, RO-4368554 and SB-258585 in animal models for schizophrenia and cognition. Abstract in Behav Pharmacol, 20 (Special issue 1): S90.
Chambon C, Paban V, Manrique C, Alescio-lautier B. (2007). Behavioral and immunohistological effects of cholinergic damage in immunolesioned rats: Alteration of c-Fos and PSA-NCAM expression. Neuroscience, 147: 893–905
Alescio-lautier B, Michel B, Herrera C, Elhamadi A, Chambon C, Touzet C, Paban V. (2007) Visual and visuospatial short-term memory in mild cognitive impairment and Alzheimer disease: role of attention. Neuropsychologia, 45: 1948-1960
Paban V, Jaffard M, Chambon C, Malafosse M, Alescio-lautier B. (2005) Time course of behavioral changes following basal forebrain cholinergic damage in rats: environmental enrichment as a therapeutic intervention. Neurosciences, 132: 13-32
Paban V, Chambon C, Jaffard M, Alescio-lautier B. (2005) Behavioral effects of basal forebrain cholinergic lesions in young adult and aging rats. Behavioral Neurosciences, 119(4): 933-945