2014 |
Lattante S.; Le Ber I.; Galimberti D.; Serpente M.; Rivaud-Péchoux S.; Camuzat A.; Clot F.; Fenoglio C.; French research network on FTD/FTD-ALS.; Scarpini E.; Brice A.; Kabashi E. Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions. Journal Article Neurobiology of Aging, 35 (11), pp. Pages 2658.e1–2658.e5, 2014. @article{Lattante2014, title = { Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions.}, author = { Lattante S. and Le Ber I. and Galimberti D. and Serpente M. and Rivaud-Péchoux S. and Camuzat A. and Clot F. and Fenoglio C. and French research network on FTD/FTD-ALS. and Scarpini E. and Brice A. and Kabashi E.}, doi = {10.1016/j.neurobiolaging.2014.06.023}, year = {2014}, date = {2014-11-01}, journal = {Neurobiology of Aging}, volume = {35}, number = {11}, pages = {Pages 2658.e1–2658.e5}, abstract = {TMEM106B was identified as a risk factor for frontotemporal lobar degeneration (FTD) with TAR DNA-binding protein 43 kDa inclusions. It has been reported that variants in this gene are genetic modifiers of the disease and that this association is stronger in patients carrying a GRN mutation or a pathogenic expansion in chromosome 9 open reading frame 72 (C9orf72) gene. Here, we investigated the contribution of TMEM106B polymorphisms in cohorts of FTD and FTD with amyotrophic lateral sclerosis patients from France and Italy. Patients carrying the C9orf72 expansion (n = 145) and patients with GRN mutations (n = 76) were compared with a group of FTD patients (n = 384) negative for mutations and to a group of healthy controls (n = 552). In our cohorts, the presence of the C9orf72 expansion did not correlate with TMEM106B genotypes but the association was very strong in individuals with pathogenic GRN mutations (p = 9.54 × 10(-6)). Our data suggest that TMEM106B genotypes differ in FTD patient cohorts and strengthen the protective role of TMEM106B in GRN carriers. Further studies are needed to determine whether TMEM106B polymorphisms are associated with other genetic causes for FTD, including C9orf72 repeat expansions.}, keywords = {}, pubstate = {published}, tppubtype = {article} } TMEM106B was identified as a risk factor for frontotemporal lobar degeneration (FTD) with TAR DNA-binding protein 43 kDa inclusions. It has been reported that variants in this gene are genetic modifiers of the disease and that this association is stronger in patients carrying a GRN mutation or a pathogenic expansion in chromosome 9 open reading frame 72 (C9orf72) gene. Here, we investigated the contribution of TMEM106B polymorphisms in cohorts of FTD and FTD with amyotrophic lateral sclerosis patients from France and Italy. Patients carrying the C9orf72 expansion (n = 145) and patients with GRN mutations (n = 76) were compared with a group of FTD patients (n = 384) negative for mutations and to a group of healthy controls (n = 552). In our cohorts, the presence of the C9orf72 expansion did not correlate with TMEM106B genotypes but the association was very strong in individuals with pathogenic GRN mutations (p = 9.54 × 10(-6)). Our data suggest that TMEM106B genotypes differ in FTD patient cohorts and strengthen the protective role of TMEM106B in GRN carriers. Further studies are needed to determine whether TMEM106B polymorphisms are associated with other genetic causes for FTD, including C9orf72 repeat expansions. |
Caroline CHAMBON; Herrera C; Romaiguere P; Veronique PABAN; Béatrice Alescio-Lautier Benefits of computer-based memory and attention training in healthy older adults. Journal Article Psycholology of Aging, 29 (3), pp. 731-43, 2014. @article{C2014, title = {Benefits of computer-based memory and attention training in healthy older adults. }, author = {Caroline CHAMBON and Herrera C and Romaiguere P and Veronique PABAN and Béatrice Alescio-Lautier}, doi = {10.1037/a0037477}, year = {2014}, date = {2014-09-16}, journal = {Psycholology of Aging}, volume = {29}, number = {3}, pages = {731-43}, abstract = {Multifactorial cognitive training programs have a positive effect on cognition in healthy older adults. Among the age-sensitive cognitive domains, episodic memory is the most affected. In the present study, we evaluated the benefits on episodic memory of a computer-based memory and attention training. We targeted consciously controlled processes at encoding and minimizing processing at retrieval, by using more familiarity than recollection during recognition. Such an approach emphasizes processing at encoding and prevents subjects from reinforcing their own errors. Results showed that the training improved recognition performances and induced near transfer to recall. The largest benefits, however, were for tasks with high mental load. Improvement in free recall depended on the modality to recall; semantic recall was improved but not spatial recall. In addition, a far transfer was also observed with better memory self-perception and self-esteem of the participants. Finally, at 6-month follow up, maintenance of benefits was observed only for semantic free recall. The challenge now is to corroborate far transfer by objective measures of everyday life executive functioning.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Multifactorial cognitive training programs have a positive effect on cognition in healthy older adults. Among the age-sensitive cognitive domains, episodic memory is the most affected. In the present study, we evaluated the benefits on episodic memory of a computer-based memory and attention training. We targeted consciously controlled processes at encoding and minimizing processing at retrieval, by using more familiarity than recollection during recognition. Such an approach emphasizes processing at encoding and prevents subjects from reinforcing their own errors. Results showed that the training improved recognition performances and induced near transfer to recall. The largest benefits, however, were for tasks with high mental load. Improvement in free recall depended on the modality to recall; semantic recall was improved but not spatial recall. In addition, a far transfer was also observed with better memory self-perception and self-esteem of the participants. Finally, at 6-month follow up, maintenance of benefits was observed only for semantic free recall. The challenge now is to corroborate far transfer by objective measures of everyday life executive functioning. |
Claude Touzet; Christopher Kermorvant; Hervé Glotin A Biologically Plausible SOM Representation of the Orthographic Form of 50,000 French Words Book Chapter Villmann Th., Schleif Kaden Lange F -M M M (Ed.): 295 , pp. 303-312, Springer, Advances in Self-Organizing Maps and Learning Vector Quantization, 2014, ISBN: 9783319076959. @inbook{b, title = {A Biologically Plausible SOM Representation of the Orthographic Form of 50,000 French Words}, author = {Claude Touzet and Christopher Kermorvant and Hervé Glotin}, editor = {Villmann, Th., Schleif, F.-M., Kaden, M., Lange, M. }, url = {http://www.touzet.org/Claude/Web-Fac-Claude/Publi/WSOM2014/Touzet-WSOM2014.pdf}, isbn = {9783319076959}, year = {2014}, date = {2014-07-28}, volume = {295}, pages = {303-312}, publisher = {Springer}, edition = {Advances in Self-Organizing Maps and Learning Vector Quantization}, series = {AISC}, abstract = {Recently, an important aspect of human visual word recognition has been characterized. The letter position is encoded in our brain using an explicit representation of order based on letter pairs: the open-bigram coding. We hypothesize that spelling has evolved in order to minimize reading errors. Therefore, word recognition using bigrams - instead of letters - should be more efficient. First, we study the infuence of the size of the neighborhood, which defines the number of bigrams per word, on the performance of the matching between bigrams and word. Our tests are conducted against one of the best recognition solutions used today by the industry, which matches letters to words. Secondly, we build a cortical map representation of the words in the bigram space which implies numerous experiments in order to achieve a satisfactory projection. Third, we develop an ultra-fast version of the self-organizing map in order to achieve learning in minutes instead of months.}, keywords = {}, pubstate = {published}, tppubtype = {inbook} } Recently, an important aspect of human visual word recognition has been characterized. The letter position is encoded in our brain using an explicit representation of order based on letter pairs: the open-bigram coding. We hypothesize that spelling has evolved in order to minimize reading errors. Therefore, word recognition using bigrams - instead of letters - should be more efficient. First, we study the infuence of the size of the neighborhood, which defines the number of bigrams per word, on the performance of the matching between bigrams and word. Our tests are conducted against one of the best recognition solutions used today by the industry, which matches letters to words. Secondly, we build a cortical map representation of the words in the bigram space which implies numerous experiments in order to achieve a satisfactory projection. Third, we develop an ultra-fast version of the self-organizing map in order to achieve learning in minutes instead of months. |
Le Ber I.; Van Bortel I.; Nicolas G.; Bouya-Ahmed K.; Camuzat A.; Wallon D.; De Septenville A.; Latouche M.; Lattante S.; Kabashi E.; Jornea L.; Hannequin D.; Brice A.; French research Network on FTLD/FTLD-ALS hnRNPA2B1 and hnRNPA1 mutations are rare in patients with “multisystem proteinopathy” and frontotemporal lobar degeneration phenotypes. Journal Article Neurobiology of Aging, 35 (4), pp. 934.e5–934.e6, 2014. @article{LeBer2014, title = {hnRNPA2B1 and hnRNPA1 mutations are rare in patients with “multisystem proteinopathy” and frontotemporal lobar degeneration phenotypes.}, author = {Le Ber I. and Van Bortel I. and Nicolas G. and Bouya-Ahmed K. and Camuzat A. and Wallon D. and De Septenville A. and Latouche M. and Lattante S. and Kabashi E. and Jornea L. and Hannequin D. and Brice A. and French research Network on FTLD/FTLD-ALS}, doi = {10.1016/j.neurobiolaging.2013.09.016}, year = {2014}, date = {2014-04-01}, journal = {Neurobiology of Aging}, volume = {35}, number = {4}, pages = {934.e5–934.e6}, abstract = {hnRNPA2B1 and hnRNPA1 mutations have been recently identified by exome sequencing in three families presenting with multisystem proteinopathy (MSP), a rare complex phenotype associating frontotemporal lobar degeneration (FTLD), Paget disease of bone (PDB), inclusion body myopathy (IBM), and amyotrophic lateral sclerosis (ALS). No study has evaluated the exact frequency of these genes in cohorts of MSP or FTD patients so far. We sequenced both genes in 17 patients with MSP phenotypes, and in 60 patients with FTLD and FTLD-ALS to test whether mutations could be implicated in the pathogenesis of these disorders. No disease-causing mutation was identified. We conclude that hnRNPA2B1 and hnRNPA1 mutations are rare in MSP and FTLD spectrum of diseases, although further investigations in larger populations are needed.}, keywords = {}, pubstate = {published}, tppubtype = {article} } hnRNPA2B1 and hnRNPA1 mutations have been recently identified by exome sequencing in three families presenting with multisystem proteinopathy (MSP), a rare complex phenotype associating frontotemporal lobar degeneration (FTLD), Paget disease of bone (PDB), inclusion body myopathy (IBM), and amyotrophic lateral sclerosis (ALS). No study has evaluated the exact frequency of these genes in cohorts of MSP or FTD patients so far. We sequenced both genes in 17 patients with MSP phenotypes, and in 60 patients with FTLD and FTLD-ALS to test whether mutations could be implicated in the pathogenesis of these disorders. No disease-causing mutation was identified. We conclude that hnRNPA2B1 and hnRNPA1 mutations are rare in MSP and FTLD spectrum of diseases, although further investigations in larger populations are needed. |
Claude Touzet Hypnose, sommeil, placebo ? Les réponses de la Théorie neuronale de la Cognition - Tome 2 Book 2014, ISBN: 978-2-919411-02-3. @book{b, title = {Hypnose, sommeil, placebo ? Les réponses de la Théorie neuronale de la Cognition - Tome 2}, author = {Claude Touzet}, editor = {La Machotte}, url = {http://www.machotte.fr/TnC2/}, isbn = {978-2-919411-02-3}, year = {2014}, date = {2014-03-05}, abstract = {"Hypnose, sommeil, placebo" traite : - l'hypnose, le plaisir, le sommeil et les rêves, la responsabilité, l'effet placebo et la schizophrénie. Il intègre des aspects encore plus controversés, comme : - le paranormal, - l'influence de l'intention sur la réalité, - le « véritable » intérêt des religions, - la dynamisation de l'eau et - les mécanismes d'actions de l'homéopathie.}, keywords = {}, pubstate = {published}, tppubtype = {book} } "Hypnose, sommeil, placebo" traite : - l'hypnose, le plaisir, le sommeil et les rêves, la responsabilité, l'effet placebo et la schizophrénie. Il intègre des aspects encore plus controversés, comme : - le paranormal, - l'influence de l'intention sur la réalité, - le « véritable » intérêt des religions, - la dynamisation de l'eau et - les mécanismes d'actions de l'homéopathie. |
Clot F.; Rovelet-Lecrux A.; Lamari F.; Noël S.; Keren B.; Camuzat A.; Michon A.; Jornea L.; Laudier B.; de Septenville A.; Caroppo P.; Campion D.; Cazeneuve C.; Brice A.; LeGuern E.; Le Ber I.; French clinical & genetic research network on FTLD/FTLD-ALS Partial deletions of the GRN gene are a cause of frontotemporal lobar degeneration. Journal Article neurogenetics, 2014. @article{Clot2014, title = {Partial deletions of the GRN gene are a cause of frontotemporal lobar degeneration.}, author = {Clot F. and Rovelet-Lecrux A. and Lamari F. and Noël S. and Keren B. and Camuzat A. and Michon A. and Jornea L. and Laudier B. and de Septenville A. and Caroppo P. and Campion D. and Cazeneuve C. and Brice A. and LeGuern E. and Le Ber I. and French clinical & genetic research network on FTLD/FTLD-ALS}, doi = {10.1007/s10048-014-0389-x}, year = {2014}, date = {2014-01-28}, journal = {neurogenetics}, abstract = {Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar degeneration (FTLD). Most known GRN mutations are null mutations, such as nonsense and frameshift mutations, which create a premature stop codon resulting in loss of function of the progranulin protein. Complete or near-complete genomic GRN deletions have also been found in three families, but heterozygous partial deletions that remove only one or two exons have not been reported to date. In this study, we analysed three unrelated FTLD patients with low plasma progranulin levels but no point GRN mutations by multiplex ligation-dependent probe amplification (MLPA) and quantitative multiplex polymerase chain reaction of short fluorescent fragments (QMPSF). We detected two heterozygous partial GRN deletions in two patients. One deletion removed exon 1 and part of intron 1. The second deletion was complex: it removed 1,410 bp extending from the part of intron 1 to the part of exon 3, with a small 5-bp insertion at the breakpoint junction (c.-7-1121_159delinsGATCA). Our findings illustrate the usefulness of a quantitative analysis in addition to GRN gene sequencing for a comprehensive genetic diagnosis of FTLD, particularly in patients with low plasma progranulin levels.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar degeneration (FTLD). Most known GRN mutations are null mutations, such as nonsense and frameshift mutations, which create a premature stop codon resulting in loss of function of the progranulin protein. Complete or near-complete genomic GRN deletions have also been found in three families, but heterozygous partial deletions that remove only one or two exons have not been reported to date. In this study, we analysed three unrelated FTLD patients with low plasma progranulin levels but no point GRN mutations by multiplex ligation-dependent probe amplification (MLPA) and quantitative multiplex polymerase chain reaction of short fluorescent fragments (QMPSF). We detected two heterozygous partial GRN deletions in two patients. One deletion removed exon 1 and part of intron 1. The second deletion was complex: it removed 1,410 bp extending from the part of intron 1 to the part of exon 3, with a small 5-bp insertion at the breakpoint junction (c.-7-1121_159delinsGATCA). Our findings illustrate the usefulness of a quantitative analysis in addition to GRN gene sequencing for a comprehensive genetic diagnosis of FTLD, particularly in patients with low plasma progranulin levels. |
POLYDOR J-P.; MICHEL B.F. Alzheimer, empathie et neurones miroirs : la représentation manipulable. Book Chapter Représentations et maladies neurodégénératives, pp. 205-213, 2014. @inbook{Polydor2014, title = {Alzheimer, empathie et neurones miroirs : la représentation manipulable.}, author = {POLYDOR J-P. and MICHEL B.F.}, year = {2014}, date = {2014-01-17}, booktitle = {Représentations et maladies neurodégénératives}, pages = {205-213}, keywords = {}, pubstate = {published}, tppubtype = {inbook} } |
SAMBUCHI N.; CHEN F.; BARTOLIN A.; GALLANT C.; MURACCIOLI I.; SAINT-JEAN J-C.; ROUYER C.; BENSA P.; TAMMAM D.; GEDA Y.E.; MICHEL B.F. Représentation de soi et cognition modèles et méthodes d’évaluation. Book Chapter Représentations et maladies neurodégénératives., pp. 17-40, 2014. @inbook{Sambuchi2014, title = {Représentation de soi et cognition modèles et méthodes d’évaluation.}, author = {SAMBUCHI N. and CHEN F. and BARTOLIN A. and GALLANT C. and MURACCIOLI I. and SAINT-JEAN J-C. and ROUYER C. and BENSA P. and TAMMAM D. and GEDA Y.E. and MICHEL B.F. }, year = {2014}, date = {2014-01-17}, booktitle = {Représentations et maladies neurodégénératives.}, pages = {17-40}, keywords = {}, pubstate = {published}, tppubtype = {inbook} } |
MICHEL B.F.; DEROUESNE C.; MURRAY M.; BECKER H.; BOEVE B.F. Représentation de soi et syndromes parkinsonien. Signe de la main étrangère dans la Dégénérescence Cortico-Basale. Journal Article pp. 113-126, 2014. @article{Michel2014, title = {Représentation de soi et syndromes parkinsonien. Signe de la main étrangère dans la Dégénérescence Cortico-Basale.}, author = {MICHEL B.F. and DEROUESNE C. and MURRAY M. and BECKER H. and BOEVE B.F.}, year = {2014}, date = {2014-01-17}, booktitle = {Représentations et maladies neurodégénératives}, pages = {113-126}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
BENSA P.; SAINT-JEAN J-C.; ROUYER C.; TAMMAM D.; MURRAY M.; MICHEL B.F. Troubles de la Représentation d’Autrui dans les Dégénérescences Lobaires Fronto-Temporales. Journal Article pp. 151-166, 2014. @article{Bensa2014, title = {Troubles de la Représentation d’Autrui dans les Dégénérescences Lobaires Fronto-Temporales.}, author = {BENSA P. and SAINT-JEAN J-C. and ROUYER C. and TAMMAM D. and MURRAY M. and MICHEL B.F.}, year = {2014}, date = {2014-01-17}, booktitle = {Représentations et maladies neurodégénératives}, pages = {151-166}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Béatrice ALESCIO-LAUTIER; Caroline CHAMBON Les méthodes de remédiation de la mémoire dans le cadre du vieillissement cognitif et des pathologies qui lui sont liées. Book Chapter de Provence, Presse Universitaire (Ed.): 2014. @inbook{C2014b, title = {Les méthodes de remédiation de la mémoire dans le cadre du vieillissement cognitif et des pathologies qui lui sont liées. }, author = {Béatrice ALESCIO-LAUTIER and Caroline CHAMBON}, editor = {Presse Universitaire de Provence}, year = {2014}, date = {2014-01-16}, keywords = {}, pubstate = {published}, tppubtype = {inbook} } |
Christian Xerri; Yoh'i Zennou-Azogui Early and moderate sensory stimulation exerts a protective effect on perilesion representations of somatosensory cortex after focal ischemic damage Journal Article PloS One, 9 (6), pp. e99767, 2014, ISSN: 1932-6203. @article{xerri_early_2014, title = {Early and moderate sensory stimulation exerts a protective effect on perilesion representations of somatosensory cortex after focal ischemic damage}, author = { Christian Xerri and Yoh'i Zennou-Azogui}, issn = {1932-6203}, year = {2014}, date = {2014-01-01}, journal = {PloS One}, volume = {9}, number = {6}, pages = {e99767}, abstract = {Previous studies have shown that intensive training within an early critical time window after focal cortical ischemia increases the area of damaged tissue and is detrimental to behavioral recovery. We postulated that moderate stimulation initiated soon after the lesion could have protective effects on peri-infarct cortical somatotopic representations. Therefore, we have assessed the effects of mild cutaneous stimulation delivered in an attention-demanding behavioral context on the functional organization of the perilesion somatosensory cortex using high-density electrophysiological mapping. We compared the effects of 6-day training initiated on the 3rd day postlesion (early training; ET) to those of same-duration training started on the 8th day (delayed training; DT). Our findings confirm previous work showing that the absence of training aggravates representational loss in the perilesion zone. In addition, ET was found to be sufficient to limit expansion of the ischemic lesion and reduce tissue loss, and substantially maintain the neuronal responsiveness to tactile stimulation, thereby preserving somatotopic map arrangement in the peri-infarct cortical territories. By contrast, DT did not prevent tissue loss and only partially reinstated lost representations in a use-dependent manner within the spared peri-infarct cortical area. This study differentiates the effects of early versus delayed training on perilesion tissue and cortical map reorganization, and underscores the neuroprotective influence of mild rehabilitative stimulation on neuronal response properties in the peri-infarct cortex during an early critical period.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Previous studies have shown that intensive training within an early critical time window after focal cortical ischemia increases the area of damaged tissue and is detrimental to behavioral recovery. We postulated that moderate stimulation initiated soon after the lesion could have protective effects on peri-infarct cortical somatotopic representations. Therefore, we have assessed the effects of mild cutaneous stimulation delivered in an attention-demanding behavioral context on the functional organization of the perilesion somatosensory cortex using high-density electrophysiological mapping. We compared the effects of 6-day training initiated on the 3rd day postlesion (early training; ET) to those of same-duration training started on the 8th day (delayed training; DT). Our findings confirm previous work showing that the absence of training aggravates representational loss in the perilesion zone. In addition, ET was found to be sufficient to limit expansion of the ischemic lesion and reduce tissue loss, and substantially maintain the neuronal responsiveness to tactile stimulation, thereby preserving somatotopic map arrangement in the peri-infarct cortical territories. By contrast, DT did not prevent tissue loss and only partially reinstated lost representations in a use-dependent manner within the spared peri-infarct cortical area. This study differentiates the effects of early versus delayed training on perilesion tissue and cortical map reorganization, and underscores the neuroprotective influence of mild rehabilitative stimulation on neuronal response properties in the peri-infarct cortex during an early critical period. |
Christophe Lopez; Olaf Blanke Nobel Prize centenary: Robert Bárány and the vestibular system Journal Article Current Biology, 24 (21), pp. R1026–1028, 2014, ISSN: 1879-0445. @article{lopez_nobel_2014, title = {Nobel Prize centenary: Robert Bárány and the vestibular system}, author = { Christophe Lopez and Olaf Blanke}, issn = {1879-0445}, year = {2014}, date = {2014-01-01}, journal = {Current Biology}, volume = {24}, number = {21}, pages = {R1026--1028}, abstract = {The hundredth anniversary of Robert Bárány's Nobel Prize in Medicine offers the opportunity to highlight the importance of his discoveries on the physiology and pathophysiology of the vestibular organs. Bárány developed the method of caloric vestibular stimulation that revolutionized the investigation of the semicircular canals and that is still widely used today. Caloric vestibular stimulation launched experimental vestibular research that was relevant to comprehend the evolution of human locomotion, and Bárány's tests continue to be used in neuroscience to understand the influence of vestibular signals on bodily perceptions, cognition and emotions. Only during the last 20 years has caloric vestibular stimulation been merged with brain imaging to localize the human vestibular cortex.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The hundredth anniversary of Robert Bárány's Nobel Prize in Medicine offers the opportunity to highlight the importance of his discoveries on the physiology and pathophysiology of the vestibular organs. Bárány developed the method of caloric vestibular stimulation that revolutionized the investigation of the semicircular canals and that is still widely used today. Caloric vestibular stimulation launched experimental vestibular research that was relevant to comprehend the evolution of human locomotion, and Bárány's tests continue to be used in neuroscience to understand the influence of vestibular signals on bodily perceptions, cognition and emotions. Only during the last 20 years has caloric vestibular stimulation been merged with brain imaging to localize the human vestibular cortex. |
C. Xerri; Y. Zennou-Azogui; K. Sadlaoud; D. Sauvajon Interplay between intra- and interhemispheric remodeling of neural networks as a substrate of functional recovery after stroke: Adaptive versus maladaptive reorganization Journal Article Neuroscience, 2014, ISSN: 1873-7544. @article{xerri_interplay_2014, title = {Interplay between intra- and interhemispheric remodeling of neural networks as a substrate of functional recovery after stroke: Adaptive versus maladaptive reorganization}, author = { C. Xerri and Y. Zennou-Azogui and K. Sadlaoud and D. Sauvajon}, issn = {1873-7544}, year = {2014}, date = {2014-01-01}, journal = {Neuroscience}, abstract = {Brain injuries such as focal stroke initiate a myriad of neural events leading to local and remote alterations in cerebral networks. The neurochemical and neurophysiological mechanisms underlying these postlesion changes raise the question of their beneficial or adverse effects on functional recovery. In this review, we aim to reconcile findings from animal and patients studies using a "from cellular-to network-levels" perspective to gain further insights into the neuroplasticity mechanisms underlying recovery of sensorimotor functions. Ultimately, an integrative view of the multiple facets of poststroke changes should give an impetus to novel neurorehabilitation strategies by providing evidence of how neuroscience findings can be translated and operationalized within the context of restorative stroke.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Brain injuries such as focal stroke initiate a myriad of neural events leading to local and remote alterations in cerebral networks. The neurochemical and neurophysiological mechanisms underlying these postlesion changes raise the question of their beneficial or adverse effects on functional recovery. In this review, we aim to reconcile findings from animal and patients studies using a "from cellular-to network-levels" perspective to gain further insights into the neuroplasticity mechanisms underlying recovery of sensorimotor functions. Ultimately, an integrative view of the multiple facets of poststroke changes should give an impetus to novel neurorehabilitation strategies by providing evidence of how neuroscience findings can be translated and operationalized within the context of restorative stroke. |
Elisa Raffaella Ferrè; Christophe Lopez; Patrick Haggard Anchoring the self to the body: vestibular contribution to the sense of self Journal Article Psychological Science, 25 (11), pp. 2106–2108, 2014, ISSN: 1467-9280. @article{ferre_anchoring_2014, title = {Anchoring the self to the body: vestibular contribution to the sense of self}, author = { Elisa Raffaella Ferrè and Christophe Lopez and Patrick Haggard}, issn = {1467-9280}, year = {2014}, date = {2014-01-01}, journal = {Psychological Science}, volume = {25}, number = {11}, pages = {2106--2108}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Laure Mazzola; Christophe Lopez; Isabelle Faillenot; Florian Chouchou; François Mauguière; Jean Isnard Vestibular responses to direct stimulation of the human insular cortex Journal Article Annals of Neurology, 76 (4), pp. 609–619, 2014, ISSN: 1531-8249. @article{mazzola_vestibular_2014, title = {Vestibular responses to direct stimulation of the human insular cortex}, author = { Laure Mazzola and Christophe Lopez and Isabelle Faillenot and Florian Chouchou and François Mauguière and Jean Isnard}, issn = {1531-8249}, year = {2014}, date = {2014-01-01}, journal = {Annals of Neurology}, volume = {76}, number = {4}, pages = {609--619}, abstract = {OBJECTIVE: The present study provides a functional mapping of vestibular responses in the human insular cortex. METHODS: A total of 642 electrical stimulations of the insula were performed in 219 patients, using stereotactically implanted depth electrodes, during the presurgical evaluation of drug-refractory partial epilepsy. We retrospectively identified 41 contacts where stimulation elicited vestibular sensations (VSs) and analyzed their location with respect to (1) their stereotactic coordinates (for all contacts), (2) the anatomy of insula gyri (for 20 vestibular sites), and (3) the probabilistic cytoarchitectonic maps of the insula (for 9 vestibular sites). RESULTS: VSs occurred in 7.6% of the 541 evoked sensations after electrical stimulations of the insula. VSs were mostly obtained after stimulation of the posterior insula, that is, in the granular insular cortex and the postcentral insular gyrus. The data also suggest a spatial segregation of the responses in the insula, with the rotatory and translational VSs being evoked at more posterior stimulation sites than other less definable VSs. No left-right differences were observed. INTERPRETATION: These results demonstrate vestibular sensory processing in the insula that is centered on its posterior part. The present data add to the understanding of the multiple sensory functions of the insular cortex and of the cortical processing of vestibular signals. The data also indicate that lesion or dysfunction in the posterior insula should be considered during the evaluation of vestibular epileptic seizures. Ann Neurol 2014;76:609-619.}, keywords = {}, pubstate = {published}, tppubtype = {article} } OBJECTIVE: The present study provides a functional mapping of vestibular responses in the human insular cortex. METHODS: A total of 642 electrical stimulations of the insula were performed in 219 patients, using stereotactically implanted depth electrodes, during the presurgical evaluation of drug-refractory partial epilepsy. We retrospectively identified 41 contacts where stimulation elicited vestibular sensations (VSs) and analyzed their location with respect to (1) their stereotactic coordinates (for all contacts), (2) the anatomy of insula gyri (for 20 vestibular sites), and (3) the probabilistic cytoarchitectonic maps of the insula (for 9 vestibular sites). RESULTS: VSs occurred in 7.6% of the 541 evoked sensations after electrical stimulations of the insula. VSs were mostly obtained after stimulation of the posterior insula, that is, in the granular insular cortex and the postcentral insular gyrus. The data also suggest a spatial segregation of the responses in the insula, with the rotatory and translational VSs being evoked at more posterior stimulation sites than other less definable VSs. No left-right differences were observed. INTERPRETATION: These results demonstrate vestibular sensory processing in the insula that is centered on its posterior part. The present data add to the understanding of the multiple sensory functions of the insular cortex and of the cortical processing of vestibular signals. The data also indicate that lesion or dysfunction in the posterior insula should be considered during the evaluation of vestibular epileptic seizures. Ann Neurol 2014;76:609-619. |
Liliane Borel; Béatrice Alescio-Lautier Posture and cognition in the elderly: interaction and contribution to the rehabilitation strategies Journal Article Neurophysiologie Clinique = Clinical Neurophysiology, 44 (1), pp. 95–107, 2014, ISSN: 1769-7131. @article{borel_posture_2014, title = {Posture and cognition in the elderly: interaction and contribution to the rehabilitation strategies}, author = { Liliane Borel and Béatrice Alescio-Lautier}, issn = {1769-7131}, year = {2014}, date = {2014-01-01}, journal = {Neurophysiologie Clinique = Clinical Neurophysiology}, volume = {44}, number = {1}, pages = {95--107}, abstract = {In this paper we review the effects of aging on sensory systems and their impact on posture, balance and gait. We also address cognitive aging and attempt to specify which altered cognitive functions negatively impact balance and walking. The role of cognition in postural control is tested with dual-task experiments. This situation results in deleterious effects due to an attentional overload. Given the human cognitive system has limited capacities, we propose that simultaneously performing two tasks depends on the capacity of each individual to perform these tasks on a continuum between automatic execution to highly controlled performance. A level of maximum control exceeds the subject's attentional capacity, which makes it impossible to perform both tasks simultaneously. The subject therefore prioritizes one of the tasks. We use representative dual-task studies from the literature to illustrate the relationship between the different cognitive components and their impact on the control of posture and gait in elderly subjects with altered cognitive capacities and with elderly subjects who are fallers or who have altered sensory-motor capacities. Recently this postural-cognitive relationship was addressed with a new approach. We report how cognitive training can improve dual-task management and we attempt to define the cognitive mechanisms that may be responsible for better postural balance.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In this paper we review the effects of aging on sensory systems and their impact on posture, balance and gait. We also address cognitive aging and attempt to specify which altered cognitive functions negatively impact balance and walking. The role of cognition in postural control is tested with dual-task experiments. This situation results in deleterious effects due to an attentional overload. Given the human cognitive system has limited capacities, we propose that simultaneously performing two tasks depends on the capacity of each individual to perform these tasks on a continuum between automatic execution to highly controlled performance. A level of maximum control exceeds the subject's attentional capacity, which makes it impossible to perform both tasks simultaneously. The subject therefore prioritizes one of the tasks. We use representative dual-task studies from the literature to illustrate the relationship between the different cognitive components and their impact on the control of posture and gait in elderly subjects with altered cognitive capacities and with elderly subjects who are fallers or who have altered sensory-motor capacities. Recently this postural-cognitive relationship was addressed with a new approach. We report how cognitive training can improve dual-task management and we attempt to define the cognitive mechanisms that may be responsible for better postural balance. |
Véronique Paban; C. Manrique; M. Filali; S. Maunoir-Regimbal; F. Fauvelle; Béatrice Alescio-Lautier Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model Journal Article Neuropharmacology, 76 Pt A , pp. 68–79, 2014, ISSN: 1873-7064. @article{paban_therapeutic_2014, title = {Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model}, author = { Véronique Paban and C. Manrique and M. Filali and S. Maunoir-Regimbal and F. Fauvelle and Béatrice Alescio-Lautier}, issn = {1873-7064}, year = {2014}, date = {2014-01-01}, journal = {Neuropharmacology}, volume = {76 Pt A}, pages = {68--79}, abstract = {Methylene blue (MB) belongs to the phenothiazinium family. It has been used to treat a variety of human conditions and has beneficial effects on the central nervous system in rodents with and without brain alteration. The present study was designed to test whether chronic MB treatment taken after (therapeutic effect) or before (preventive effect) the onset of beta-amyloid pathology influences cognition in a transgenic mouse model (APP/PS1). In addition, the present study aims at revealing whether these behavioral effects might be related to brain alteration in beta-amyloid deposition. To this end, we conducted an in vivo study and compared two routes of drug administration, drinking water versus intraperitoneal injection. Results showed that transgenic mice treated with MB orally or following intraperitoneal injection were protected from cognitive impairments in a variety of social, learning, and exploratory tasks. Immunoreactive beta-amyloid deposition was significantly reduced in the hippocampus and adjacent cortex in MB-treated transgenic mice. Interestingly, these beneficial effects were observed independently of beta-amyloid load at the time of MB treatment. This suggests that MB treatment is beneficial at both therapeutic and preventive levels. Using solid-state High Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HRMAS-NMR), we showed that MB administration after the onset of amyloid pathology significantly restored the concentration of two metabolites related to mitochondrial metabolism, namely alanine and lactate. We conclude that MB might be useful for the therapy and prevention of Alzheimer's disease. This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Methylene blue (MB) belongs to the phenothiazinium family. It has been used to treat a variety of human conditions and has beneficial effects on the central nervous system in rodents with and without brain alteration. The present study was designed to test whether chronic MB treatment taken after (therapeutic effect) or before (preventive effect) the onset of beta-amyloid pathology influences cognition in a transgenic mouse model (APP/PS1). In addition, the present study aims at revealing whether these behavioral effects might be related to brain alteration in beta-amyloid deposition. To this end, we conducted an in vivo study and compared two routes of drug administration, drinking water versus intraperitoneal injection. Results showed that transgenic mice treated with MB orally or following intraperitoneal injection were protected from cognitive impairments in a variety of social, learning, and exploratory tasks. Immunoreactive beta-amyloid deposition was significantly reduced in the hippocampus and adjacent cortex in MB-treated transgenic mice. Interestingly, these beneficial effects were observed independently of beta-amyloid load at the time of MB treatment. This suggests that MB treatment is beneficial at both therapeutic and preventive levels. Using solid-state High Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HRMAS-NMR), we showed that MB administration after the onset of amyloid pathology significantly restored the concentration of two metabolites related to mitochondrial metabolism, namely alanine and lactate. We conclude that MB might be useful for the therapy and prevention of Alzheimer's disease. This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'. |
Liliane Borel; Christine Redon-Zouiteni; Pierre Cauvin; Michel Dumitrescu; Arnaud Devèze; Jacques Magnan; Patrick Péruch Unilateral vestibular loss impairs external space representation Journal Article PloS One, 9 (2), pp. e88576, 2014, ISSN: 1932-6203. @article{borel_unilateral_2014, title = {Unilateral vestibular loss impairs external space representation}, author = { Liliane Borel and Christine Redon-Zouiteni and Pierre Cauvin and Michel Dumitrescu and Arnaud Devèze and Jacques Magnan and Patrick Péruch}, issn = {1932-6203}, year = {2014}, date = {2014-01-01}, journal = {PloS One}, volume = {9}, number = {2}, pages = {e88576}, abstract = {The vestibular system is responsible for a wide range of postural and oculomotor functions and maintains an internal, updated representation of the position and movement of the head in space. In this study, we assessed whether unilateral vestibular loss affects external space representation. Patients with Menière's disease and healthy participants were instructed to point to memorized targets in near (peripersonal) and far (extrapersonal) spaces in the absence or presence of a visual background. These individuals were also required to estimate their body pointing direction. Menière's disease patients were tested before unilateral vestibular neurotomy and during the recovery period (one week and one month after the operation), and healthy participants were tested at similar times. Unilateral vestibular loss impaired the representation of both the external space and the body pointing direction: in the dark, the configuration of perceived targets was shifted toward the lesioned side and compressed toward the contralesioned hemifield, with higher pointing error in the near space. Performance varied according to the time elapsed after neurotomy: deficits were stronger during the early stages, while gradual compensation occurred subsequently. These findings provide the first demonstration of the critical role of vestibular signals in the representation of external space and of body pointing direction in the early stages after unilateral vestibular loss.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The vestibular system is responsible for a wide range of postural and oculomotor functions and maintains an internal, updated representation of the position and movement of the head in space. In this study, we assessed whether unilateral vestibular loss affects external space representation. Patients with Menière's disease and healthy participants were instructed to point to memorized targets in near (peripersonal) and far (extrapersonal) spaces in the absence or presence of a visual background. These individuals were also required to estimate their body pointing direction. Menière's disease patients were tested before unilateral vestibular neurotomy and during the recovery period (one week and one month after the operation), and healthy participants were tested at similar times. Unilateral vestibular loss impaired the representation of both the external space and the body pointing direction: in the dark, the configuration of perceived targets was shifted toward the lesioned side and compressed toward the contralesioned hemifield, with higher pointing error in the near space. Performance varied according to the time elapsed after neurotomy: deficits were stronger during the early stages, while gradual compensation occurred subsequently. These findings provide the first demonstration of the critical role of vestibular signals in the representation of external space and of body pointing direction in the early stages after unilateral vestibular loss. |
Patricia Romaiguère; Bruno Nazarian; Muriel Roth; Jean-Luc Anton; Olivier Felician Lateral occipitotemporal cortex and action representation Journal Article Neuropsychologia, 56 , pp. 167–177, 2014, ISSN: 1873-3514. @article{romaiguere_lateral_2014, title = {Lateral occipitotemporal cortex and action representation}, author = { Patricia Romaiguère and Bruno Nazarian and Muriel Roth and Jean-Luc Anton and Olivier Felician}, issn = {1873-3514}, year = {2014}, date = {2014-01-01}, journal = {Neuropsychologia}, volume = {56}, pages = {167--177}, abstract = {Representation of body and body movements is essential for identifying others intentions or actions or for learning from them. Over the last 10 years, a large collection of research has demonstrated that body representations are distributed across a widely distributed brain network. In this functional magnetic resonance imaging study, we focus on lateral occipitotemporal cortex (LOTC), a recently identified brain region that could represent the body in a multisensory and dynamic manner. We addressed the question of LOTC involvement in visual processing of others׳ actions through a factorial analysis that manipulated the meaning of an observed action, completed by a psychophysiological interaction analysis. The results show that only left LOTC was significantly activated in relation to others׳ actions meaning. In addition, only left LOTC was activated during both action observation and action production but it was more dorsal than the activation related to the meaning of observed actions. Furthermore, the psychophysiological interaction analysis showed that when watching meaningless actions, the more dorsal part of the LOTC (the area active during both action production and action observation) had higher functional connectivity with primary visual areas while the more ventral part (that responded to action meaning) had higher correlation with anterior cingulate and medioprefrontal cortices. Taken together these results plead in favour of a strong implication of left LOTC in action observation and understanding, with a possible functional specialisation between the more ventral and the more dorsal parts of LOTC.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Representation of body and body movements is essential for identifying others intentions or actions or for learning from them. Over the last 10 years, a large collection of research has demonstrated that body representations are distributed across a widely distributed brain network. In this functional magnetic resonance imaging study, we focus on lateral occipitotemporal cortex (LOTC), a recently identified brain region that could represent the body in a multisensory and dynamic manner. We addressed the question of LOTC involvement in visual processing of others׳ actions through a factorial analysis that manipulated the meaning of an observed action, completed by a psychophysiological interaction analysis. The results show that only left LOTC was significantly activated in relation to others׳ actions meaning. In addition, only left LOTC was activated during both action observation and action production but it was more dorsal than the activation related to the meaning of observed actions. Furthermore, the psychophysiological interaction analysis showed that when watching meaningless actions, the more dorsal part of the LOTC (the area active during both action production and action observation) had higher functional connectivity with primary visual areas while the more ventral part (that responded to action meaning) had higher correlation with anterior cingulate and medioprefrontal cortices. Taken together these results plead in favour of a strong implication of left LOTC in action observation and understanding, with a possible functional specialisation between the more ventral and the more dorsal parts of LOTC. |
Diane Deroualle; Christophe Lopez Toward a vestibular contribution to social cognition Journal Article Frontiers in integrative neuroscience, 8 , pp. 16, 2014, ISSN: 1662-5145. @article{deroualle_toward_2014, title = {Toward a vestibular contribution to social cognition}, author = { Diane Deroualle and Christophe Lopez}, issn = {1662-5145}, year = {2014}, date = {2014-01-01}, journal = {Frontiers in integrative neuroscience}, volume = {8}, pages = {16}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Ibtihel Smeti; Isabelle Watabe; Etienne Savary; Arnaud Fontbonne; Azel Zine HMGA2, the Architectural Transcription Factor High Mobility Group, Is Expressed in the Developing and Mature Mouse Cochlea Journal Article PloS one, 9 (2), pp. e88757, 2014, ISSN: 1932-6203. @article{smeti_hmga2_2014, title = {HMGA2, the Architectural Transcription Factor High Mobility Group, Is Expressed in the Developing and Mature Mouse Cochlea}, author = { Ibtihel Smeti and Isabelle Watabe and Etienne Savary and Arnaud Fontbonne and Azel Zine}, issn = {1932-6203}, year = {2014}, date = {2014-01-01}, journal = {PloS one}, volume = {9}, number = {2}, pages = {e88757}, abstract = {Hmga2 protein belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins have been shown to function as architectural transcription regulators, facilitating enhanceosome formation on a variety of mammalian promoters. Hmga2 are expressed at high levels in embryonic and transformed cells. Terminally differentiated cells, however, have been reported to express only minimal, if any, Hmga2. Our previous affymetrix array data showed that Hmga2 is expressed in the developing and adult mammalian cochleas. However, the spatio-temporal expression pattern of Hmga2 in the murine cochlea remained unknown. In this study, we report the expression of Hmga2 in developing and adult cochleas using immunohistochemistry and quantitative real time PCR analysis. Immunolabeling of Hmga2 in the embryonic, postnatal, and mature cochleas showed broad Hmga2 expression in embryonic cochlea (E14.5) at the level of the developing organ of Corti in differentiating hair cells, supporting cells, in addition to immature cells in the GER and LER areas. By postnatal stage (P0-P3), Hmga2 is predominantly expressed in the hair and supporting cells, in addition to cells in the LER area. By P12, Hmga2 immunolabeling is confined to the hair cells and supporting cells. In the adult ear, Hmga2 expression is maintained in the hair and supporting cell subtypes (i.e. Deiters' cells, Hensen cells, pillar cells, inner phalangeal and border cells) in the cochlear epithelium. Using quantitative real time PCR, we found a decrease in transcript level for Hmga2 comparable to other known inner ear developmental genes (Sox2, Atoh1, Jagged1 and Hes5) in the cochlear epithelium of the adult relative to postnatal ears. These data provide for the first time the tissue-specific expression and transcription level of Hmga2 during inner ear development and suggest its potential dual role in early differentiation and maintenance of both hair and supporting cell phenotypes.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Hmga2 protein belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins have been shown to function as architectural transcription regulators, facilitating enhanceosome formation on a variety of mammalian promoters. Hmga2 are expressed at high levels in embryonic and transformed cells. Terminally differentiated cells, however, have been reported to express only minimal, if any, Hmga2. Our previous affymetrix array data showed that Hmga2 is expressed in the developing and adult mammalian cochleas. However, the spatio-temporal expression pattern of Hmga2 in the murine cochlea remained unknown. In this study, we report the expression of Hmga2 in developing and adult cochleas using immunohistochemistry and quantitative real time PCR analysis. Immunolabeling of Hmga2 in the embryonic, postnatal, and mature cochleas showed broad Hmga2 expression in embryonic cochlea (E14.5) at the level of the developing organ of Corti in differentiating hair cells, supporting cells, in addition to immature cells in the GER and LER areas. By postnatal stage (P0-P3), Hmga2 is predominantly expressed in the hair and supporting cells, in addition to cells in the LER area. By P12, Hmga2 immunolabeling is confined to the hair cells and supporting cells. In the adult ear, Hmga2 expression is maintained in the hair and supporting cell subtypes (i.e. Deiters' cells, Hensen cells, pillar cells, inner phalangeal and border cells) in the cochlear epithelium. Using quantitative real time PCR, we found a decrease in transcript level for Hmga2 comparable to other known inner ear developmental genes (Sox2, Atoh1, Jagged1 and Hes5) in the cochlear epithelium of the adult relative to postnatal ears. These data provide for the first time the tissue-specific expression and transcription level of Hmga2 during inner ear development and suggest its potential dual role in early differentiation and maintenance of both hair and supporting cell phenotypes. |
Publications 2014Soleil Digital2018-01-24T14:10:57+00:00
2014 |
Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions. Journal Article Neurobiology of Aging, 35 (11), pp. Pages 2658.e1–2658.e5, 2014. |
Benefits of computer-based memory and attention training in healthy older adults. Journal Article Psycholology of Aging, 29 (3), pp. 731-43, 2014. |
A Biologically Plausible SOM Representation of the Orthographic Form of 50,000 French Words Book Chapter Villmann Th., Schleif Kaden Lange F -M M M (Ed.): 295 , pp. 303-312, Springer, Advances in Self-Organizing Maps and Learning Vector Quantization, 2014, ISBN: 9783319076959. |
hnRNPA2B1 and hnRNPA1 mutations are rare in patients with “multisystem proteinopathy” and frontotemporal lobar degeneration phenotypes. Journal Article Neurobiology of Aging, 35 (4), pp. 934.e5–934.e6, 2014. |
Hypnose, sommeil, placebo ? Les réponses de la Théorie neuronale de la Cognition - Tome 2 Book 2014, ISBN: 978-2-919411-02-3. |
Partial deletions of the GRN gene are a cause of frontotemporal lobar degeneration. Journal Article neurogenetics, 2014. |
Alzheimer, empathie et neurones miroirs : la représentation manipulable. Book Chapter Représentations et maladies neurodégénératives, pp. 205-213, 2014. |
Représentation de soi et cognition modèles et méthodes d’évaluation. Book Chapter Représentations et maladies neurodégénératives., pp. 17-40, 2014. |
Représentation de soi et syndromes parkinsonien. Signe de la main étrangère dans la Dégénérescence Cortico-Basale. Journal Article pp. 113-126, 2014. |
Troubles de la Représentation d’Autrui dans les Dégénérescences Lobaires Fronto-Temporales. Journal Article pp. 151-166, 2014. |
Les méthodes de remédiation de la mémoire dans le cadre du vieillissement cognitif et des pathologies qui lui sont liées. Book Chapter de Provence, Presse Universitaire (Ed.): 2014. |
Early and moderate sensory stimulation exerts a protective effect on perilesion representations of somatosensory cortex after focal ischemic damage Journal Article PloS One, 9 (6), pp. e99767, 2014, ISSN: 1932-6203. |
Nobel Prize centenary: Robert Bárány and the vestibular system Journal Article Current Biology, 24 (21), pp. R1026–1028, 2014, ISSN: 1879-0445. |
Interplay between intra- and interhemispheric remodeling of neural networks as a substrate of functional recovery after stroke: Adaptive versus maladaptive reorganization Journal Article Neuroscience, 2014, ISSN: 1873-7544. |
Anchoring the self to the body: vestibular contribution to the sense of self Journal Article Psychological Science, 25 (11), pp. 2106–2108, 2014, ISSN: 1467-9280. |
Vestibular responses to direct stimulation of the human insular cortex Journal Article Annals of Neurology, 76 (4), pp. 609–619, 2014, ISSN: 1531-8249. |
Posture and cognition in the elderly: interaction and contribution to the rehabilitation strategies Journal Article Neurophysiologie Clinique = Clinical Neurophysiology, 44 (1), pp. 95–107, 2014, ISSN: 1769-7131. |
Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model Journal Article Neuropharmacology, 76 Pt A , pp. 68–79, 2014, ISSN: 1873-7064. |
Unilateral vestibular loss impairs external space representation Journal Article PloS One, 9 (2), pp. e88576, 2014, ISSN: 1932-6203. |
Lateral occipitotemporal cortex and action representation Journal Article Neuropsychologia, 56 , pp. 167–177, 2014, ISSN: 1873-3514. |
Toward a vestibular contribution to social cognition Journal Article Frontiers in integrative neuroscience, 8 , pp. 16, 2014, ISSN: 1662-5145. |
HMGA2, the Architectural Transcription Factor High Mobility Group, Is Expressed in the Developing and Mature Mouse Cochlea Journal Article PloS one, 9 (2), pp. e88757, 2014, ISSN: 1932-6203. |